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Non-invasive study of human gall bladder bile in vivo using ¹H-MR spectroscopy

The Cancer Research UK Clinical MR Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK

View larger version (102K): [in a new window]   Figure 1. (a) Transverse, (b) coronal and (c) sagittal T2 weighted images through the upper quadrant of a volunteer. The gall bladder is seen as the bright signal intensity structure at the meeting point of the dashed lines (the dashed lines are orthogonal localizer lines created by default by the system during scanning). A typical spectroscopic volume of interest (2.20 cm3) is shown centrally within the organ. The 1H-MR spectrum derived from this volunteer is given in Figure 2c.

View larger version (15K): [in a new window]   Figure 2. PRESS 60 1H-MR spectra of (a) model (b) porcine in vitro gallbladder bile and (c) human in vivo gallbladder bile. The various resonances are labelled (TMA, trimethylamine). The peak at 4.7 ppm in (c) is a residual water resonance that has not been fully suppressed during the in vivo experiment.