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Could assessment of glioma methylene lipid resonance by in vivo ¹H-MRS be of clinical value?

¹ Cancer Research UK Clinical MR Research Group and ² Department of Neuro-oncology, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK

View larger version (29K): [in a new window]   Figure 1. (a) A short echo time spectrum from a low grade tumour showing no contrast enhancement as evidenced by imaging and water 1H-MRS. The major resonances are indicated: Cho, choline; Cre, creatine; and NAA, N-acetylaspartate. (b). A short echo time spectrum from a histologically verified contrast enhancing high grade glioma. The most prominent peaks observed are the lipid methylene and methyl signals, labelled as lip(-CH2-) and lip(-CH3), respectively.

View larger version (9K): [in a new window]   Figure 2. (a) The relationship between glioma grade and the normalized lipid methylene signal. (b) The intravoxel enhancement (IVE) values determined spectroscopically and categorized by tumour grade.

View larger version (17K): [in a new window]   Figure 3. A correlation between the normalized lipid methylene signal with the percentage intravoxel enhancement (IVE). For the linear regression, r2=0.74 and p=0.0002.