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Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma

¹ Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT, ² Cancer Research Campaign Department Medical Oncology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX and ³ AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

View larger version (60K): [in a new window]   Figure 1. Transaxial section through map volumes from a patient with a glioblastoma multiforme (arrow head), acquired on day 0 (top and day 2 (bottom): (a) Time taken to achieve 90% enhancement (T90); (b) Maximal intensity change per time interval (MITR); (c) Volume transfer coefficient between plasma and the extravascular space (Ktrans); and (d) the extravascular extracellular contrast distribution volume (ve) maps. All parametric maps are colour rendered. Yellow represents high values, i.e. long T90, high MITR, high Ktrans and large ve. Dark-blue represents low values, i.e. short T90, low MITR, low Ktrans and small ve.

View larger version (33K): [in a new window]   Figure 2. Changes in measured parameters over the 2 day study period. (a) Tumour volume (vol). (b) Maximal intensity change per time interval (MITR). (c) Time taken to achieve 90% enhancement (T90). (d) R10. (e) Volume transfer coefficient beween plasma and the extravascular space (Ktrans). (f) The Extravascular extracellular contrast distribution volume (ve). Symbols represent individual patients.