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Dose dependence of the growth rate of multicellular tumour spheroids after irradiation

¹ Servicio de Radiofísica, Hospital Universitario "San Cecilio", Avda. Dr. Olóriz, 16, E-18012 Granada, ² Departamento de Radiología, Universidad de Granada, E-18071 Granada and ³ Departamento de Física Moderna, Universidad de Granada, E-18071 Granada, Spain

View larger version (18K): [in a new window]   Figure 1. Representative examples of control (a) and irradiated spheroids (b–f). Uncertainties correspond to 2 standard deviations. ---, fits obtained by fixing the initial specific growth rate and the proportional rate of decay to the values obtained for the control spheroids; —, fits obtained by fixing only the proportional rate of decay to the values obtained for the control spheroids.

View larger version (7K): [in a new window]   Figure 2. Variation of the initial specific growth rate with dose administered. Uncertainties correspond to one standard deviation. (a) Linear fit corresponding to the method used in this study. (b) Linear fit of results obtained in a similar analysis. , results obtained without normalization; , results obtained from the latter analysis and normalized to a common initial volume, as discussed in the text.

View larger version (13K): [in a new window]   Figure 3. The natural logarithm of the surviving fraction (s) as a function of the imparted dose. , results of the method used in this study; —, corresponding regression to the linear-quadratic model; -.-., results quoted by Villalobos et al [21] (•, 2 Gy dose); ..., linear-quadratic fit obtained by Núñez et al [28] (, 2 Gy dose); and - - -, results corresponding to reanalysis of data of Villalobos et al [21]. Uncertainties correspond to one standard deviation.