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British Journal of Radiology (2003) 76, 13-21
© 2003 British Institute of Radiology
doi: 10.1259/bjr/80482243
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Image features of true positive and false negative cancers in screening mammograms

S Meeson, PhD1, K C Young, PhD1, M G Wallis, FRCR2, J Cooke, MRCP, FRCR3, A Cummin3 and M L Ramsdale, MSc1

1 National Co-ordinating Centre for the Physics of Mammography, Department of Medical Physics, St. Luke's Wing, Royal Surrey County Hospital, Guildford GU2 7XX, 2 Warwickshire, Solihull & Coventry Breast Screening Centre, Coventry and Warwickshire Hospital, Stoney Stanton Road, Coventry CV1 4FH, and 3 Jarvis Breast Screening Centre, 60 Stoughton Road, Guildford GU1 1LJ, UK



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  		Figure 1. Oblique view mammogram showing the three regions of interest selected for the analysis of cancer features.

 


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  		Figure 2. Schematic showing the regions of interest used to assess distribution of cancer locations throughout the breast. The breast has been divided into five mutually exclusive anatomical regions of interest and one rectangular region of interest at the chest wall edge of the film.

 


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  		Figure 3. Histogram of the mean optical density (OD) in the main breast regions of all the mammograms used in this study. (Labels on the mean OD axis represent the mid-points of the ranges used to sort the data.)

 


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  		Figure 4. The relationship between the mean optical density (OD) in the main breast region and the mean OD in the whole cancer region of interest (ROI).

 


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  		Figure 5. Histogram showing the distribution of mean optical density (OD) in the cancer background region of interest (ROI) of all the cancer group mammograms used in this study. (Labels on the Mean OD axis represent the mid-points of the ranges used to sort the data.)

 


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  		Figure 6. Chart showing time lag between false negative screening mammogram and breast cancer being confirmed by mammography. (Labels on the lag time axis represent the upper limit of the ranges used to sort the data.)

 


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  		Figure 7. Cancer centre locations shown for both the interval cancers following false negative screen (a) and true positive screen detected cancers (b) cases.

 




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