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Functional imaging for assessment of therapy

Nuklearmedizinische Klinik und Poliklinik, Klinikum r.d. Isar, Technische Universitaet Muenchen, Ismaninger Str. 22, 81675 Muenchen, Germany

View larger version (30K): [in a new window]   Figure 1. Imaging procedures and imaging targets.

View larger version (61K): [in a new window]   Figure 2. Whole body PET imaging in a patient (50 years old, male) with non-Hodgkin (MALT) lymphoma before and after chemotherapy. Multiple sites of increased FDG uptake reflecting tumour tissue are seen at the baseline. 8 weeks after therapy, only physiological distribution of FDG can be observed, identifying successful treatment.

View larger version (21K): [in a new window]   Figure 3. FDG uptake in oesophageal cancer prior to and following therapy before surgical removal of the tumour. SUV decreases in the responding patient by over 70%, while SUV in the non-responder changes less than 30% [17].

View larger version (36K): [in a new window]   Figure 4. Visualization of alpha-v beta-3 integrins using F-18 RGD peptide in mice implanted with alpha-V beta-3 positive and negative tumours. In addition, displacement studies with cold RGD were performed, indicating low non-specific binding of F-18 RGD [24].

View larger version (33K): [in a new window]   Figure 5. PET imaging of HSV1-TK expression in the mouse model. Following injection of J-124 FIAU (thymidine analogue), the positive HSV1-TK tumour (right side) is visible. Note the low uptake in non-transfected tissue.