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Molecular imaging with PET – the future challenges

Wolfson Molecular Imaging Centre, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK

View larger version (129K): [in a new window]   Figure 1. Focal activation of regional cerebral blood flow using H2O15, showing the inner speech and inner ear of a normal subject, silently keeping language stimuli, such as telephone numbers, in working memory [2]. Reproduced with the kind permission of Dr E Paulescu and Professor C Frith.

View larger version (88K): [in a new window]   Figure 2. Focal neurotransmitter activation showing 11C-raclopride displacement during a video game based reward task, demonstrating the local release of dopamine [3]. Reproduced with the kind permission of Professor P Grasby and Macmillan Publishers Ltd.

View larger version (76K): [in a new window]   Figure 3. Visualization of microglia activation in the brain of an early dementia patient using 11C-PK-11195 [5]. Reproduced with the kind permission of Dr R Banati and Elsevier Science.

View larger version (58K): [in a new window]   Figure 4. The use of the ligand 11C-WAY100635 to measure the amount of the drug pindolol needed to be administered to achieve blockade of the 5HT1A receptor [6]. (a) Pindolol occupancy of pre-synaptic and post-synaptic 5-HT1A receptors. (b) 11C-WAY100635 binding before and after 20 mg of pindolol. Reproduced with the kind permission of Professor P Grasby and Elsevier Science.

View larger version (94K): [in a new window]   Figure 5. The uptake of 11C-temozolomide in cerebral glioma [7]. Reproduced with the kind permission of Professor P Price.