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Does radiotherapy affect the outcome of the comet assay?

W-U Müller, PhD1, T Bauch, PhD1, C Streffer, PhD1 and D VON Mallek, MD,2

1 Institut für Medizinische Strahlenbiologie and 2 Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Essen, D45122 Essen, Germany



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  		Figure 1. Comet immediately after a 2 Gy exposure in vitro.

 


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  		Figure 2. Relation between residual damage after 3 h of repair and area under curve (AuC). (---) 95% confidence intervals of the linear regression line; r2=0.62; degrees of freedom=44; p<0.01). a.u., arbitrary units.

 


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  		Figure 3. Repair characteristics of lymphocytes of tumour patients before therapy (bT), after 5 fractions of 2 Gy (dT/10) and after 10 fractions of 2 Gy (dT/20). (a) Repair kinetics up to 180 min. Figure shows arithmetic means and 95% confidence intervals. Due to methodological problems not all of the 49 patients under study could be analysed. n, number of successfully analysed patients. (b) Area under curve. Arithmetic means and 95% confidence intervals are shown. Differences among the three groups are not significant (p>0.05) using analysis of variance. a.u., arbitrary units.

 


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  		Figure 4. Initial DNA damage after 2 Gy. Arithmetic means and 95% confidence intervals are shown. bT, before therapy; dT/10, after 5 fractions of 2 Gy; dT/20, after 10 fractions of 2 Gy.

 


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  		Figure 5. Individual repair characteristics before radiotherapy. (a) Box and whisker plots of the area under curve of Figure 3bGo in dependence on the severity of side effects (0+1, n=15; 2, n=14; 3+4, n=10). (b) Repair kinetics up to 180 min of all patients analysed. a.u., arbitrary units.

 


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  		Figure 6. Effect of field size on repair capacity. Comparison was performed between the field sizes lower than the median and higher than or equal to the median. The two right-hand columns show a comparison between field sizes exceeding 1000 cm2 and all smaller field sizes. a.u., arbitrary units.

 




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