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Can contrast enhanced MRI predict the response of Graves' ophthalmopathy to orbital radiotherapy?

Departments of ¹ Radiotherapy and ² Neuroradiology, University Hospital, 37075 Göttingen, Germany

View larger version (117K): [in a new window]   Figure 1. T1 weighted fat saturated frontal image showing enlargement of extraocular muscles, especially the superior and inferior rectus muscles of both sides with marked contrast enhancement.

View larger version (52K): [in a new window]   Figure 2. T1 weighted fat saturated frontal images showing additional contrast enhacement of adjacent orbital tissue surrounding the extraocular muscles prior to orbital radiotherapy (ORT) (a), which is thought to be a sign of acute inflammation. A marked decrease in contrast enhancement and muscle size was found 3 months following ORT (b), which was accompanied by clinical improvement.

View larger version (104K): [in a new window]   Figure 3. T1 weighted fat saturated axial image showing an area of inhomogeneous contrast enhancement of an enlarged medial rectus muscle (arrow) which is judged to be fibrosis in a chronically inflamed muscle.