BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bradley, K M
Right arrow Articles by Smith, A D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bradley, K M
Right arrow Articles by Smith, A D

Serial brain MRI at 3–6 month intervals as a surrogate marker for Alzheimer's disease

K M Bradley, MRCP, FRCR1, G M Bydder, FRCR2, M M Budge, FRACP1, J V Hajnal, PhD2, S J White, DCR2, B D Ripley, PhD3 and A D Smith, DPhil1

1 Oxford Project to Investigate Memory and Ageing, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, 2 Magnetic Resonance Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, London and 3 Department of Statistics, University of Oxford, Oxford, UK



View larger version (86K):

[in a new window]
  		Figure 1. National Institute of Neurological and Communicative Disorders and Stroke Alzheimer's disease negative subject. (a) Baseline image; (b) registered image 6 months later; (c) registered difference image.

 


View larger version (81K):

[in a new window]
  		Figure 2. National Institute of Neurological and Communicative Disorders and Stroke Alzheimer's disease probable subject. (a) Baseline image; (b) registered imaged 6 months later; (c) registered difference image with black representing loss of tissue.

 


View larger version (42K):

[in a new window]
  		Figure 3. Rate of change of ventricular brain volume. MRI scans were performed at 2.5–7 month intervals, as shown by open circles for each subject. (– – –), calculated mean rate of change for each group: National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) probable (Prob), possible (Poss) and negative (Neg) for Alzheimer's disease; (•), two NINCDS Neg subjects referred with objective memory complaints.

 


View larger version (9K):

[in a new window]
  		Figure 4. Influence of age on brain ventricular volume. V:B, cerebral ventricle:total brain volume ratio.

 


View larger version (34K):

[in a new window]
  		Figure 5. Power calculation (90%) to detect a reduction in the rate of change of cerebral ventricle:total brain volume between treated and untreated groups of National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) Alzheimer's disease (AD) probable subjects, compared with NINCDS AD negative subjects.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2002 by the British Institute of Radiology.