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Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate

¹ Service d'Oncologie-Radiothérapie, Hôpital Saint-Louis APHP, 1 Ave Claude Vellefaux, 75010 Paris and ² Laboratoire de Radiotoxicologie, CEA-DSV-DRR, BP12, 91680 Bruyères-Le-Chatel, France

View larger version (93K): [in a new window]   Figure 1. (A) Clinical photograph in February 1998 of the radiation-induced fibrotic volume with a cutaneous thoracic projection of 15 cm x 11 cm fibrosis outlined and large fistulous track in the upper part of the sternum. (B) In June 2001, after 3 years of treatmentwith combined pentoxifylline-tocopherol and clodronate, total fibrosis regression (dotted line for residual skin firmness) has occurred and the fistula has closed.

View larger version (80K): [in a new window]   Figure 2. MRI, 1,5 Tesla, T2 weighted sagittal images. (A) The upper part of the sternum, with a large area of radionecrosis (arrow) in February 1998. (B) Sternum restoration with new filling tissue(arrow) combined with striking reduction of presternal radiation-induced fibrosis after 3 years of treatment with combined pentoxifylline-tocopherol and clodronate.