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Comparison of forward planned conformal radiation therapy and inverse planned intensity modulated radiation therapy for esthesioneuroblastoma

Departments of ¹ Radiotherapy and ² Medical Physics, German Cancer Research Center, INF280, 69120 Heidelberg and ³ Department of Radiotherapy, University of Heidelberg, INF400, 69120 Heidelberg, Germany

View larger version (63K): [in a new window]   Figure 1. Axial dose distribution of a patient for conformal radiation therapy (left) and intensity modulated radiation therapy (IMRT) (right) at the same level. The isodose lines are 10%, 20%, 50%, 60%, 80% and 90%. The orange colour-wash represents the 60–80% isodoses. Dose distribution is more conformal to the planning treatment volume (red line), and sparing of orbital structures is improved, using IMRT.

View larger version (33K): [in a new window]   Figure 2. Percentage of organs at risk (OAR) receiving more than clinically relevant doses as box-whisker plots for all patients. The volume of OAR receiving more than their respective tolerance doses could be reduced using intensity modulated radiation therapy.

View larger version (28K): [in a new window]   Figure 3. Example of a typical dose volume histogram of a patient for intensity modulated radiation therapy (IMRT) (back) and conformal radiation therapy (SCRT) (grey) regarding the target, left orbit, left lens and left optic nerve. Target coverage is equal in both plans. IMRT was always superior to SCRT in sparing organs at risk.