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Imaging of pulmonary manifestations in subtype B of Niemann–Pick disease

F Duchateau, MD, S Dechambre, MD and E Coche, MD

Department of Medical Imaging, Université Catholique de Louvain, Cliniques Universitaires Saint Luc, B-1200 Brussels, Belgium



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  		Figure 1. Chest radiograph: magnified view of the left lung base showing subtle Kerley B lines.

 


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  		Figure 2. High resolution CT at the level of the lower lobes demonstrates smooth thickening of interlobular septa (arrow) and subtle ground-glass opacities (arrowhead).

 


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  		Figure 3. (a) Microscopy of the bone marrow biopsy showing infiltration by histiocytes with vacuolated cytoplasm. (b) There are numerous histiocytes containing granules that stained blue with May–Grünwald–Giemsa stain ("sea blue histiocytes").

 




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