BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bomanji, J B
Right arrow Articles by Ell, P J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bomanji, J B
Right arrow Articles by Ell, P J

Functional imaging as an aid to decision-making in metastatic paraganglioma

J B Bomanji, MBBS, MSc, PhD 1 S W Hyder, MB 1 M N Gaze, MD, FRCR 2 S Gacinovic, MD, MSc 1 D C Costa, MD, PhD, FRCR 1 C Coulter, FRCR 2 and P J Ell, FRCP, FRCR 1

1 The Institute of Nuclear Medicine 2 Meyerstein Institute of Oncology, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK



View larger version (164K):

[in a new window]
  		Figure 1. Case 1. CT showing a destructive soft tissue mass in the back and lateral aspect of the right orbit, displacing the lateral rectus muscle and right globe.

 


View larger version (100K):

[in a new window]
  		Figure 2. (A) 123I-MIBG whole body image 24 h post injection, showing multiple foci of increased tracer uptake in the skull vault, spine, ribs and pelvis. (B) 131I-MIBG whole body image 7 days post therapy (12.1 GBq) shows a pattern similar to (A). (C) After approximately 36.8 GBq (993 mCi) of 131I-MIBG therapy given in three cycles, a follow-up 123I-MIBG scan shows minimal residual disease. (D) A second follow-up diagnostic 123I-MIBG scan shows progression of disease. MIBG-avid lesions are noted in the spine, ribs and soft tissues along the paraaortic region.

 


View larger version (95K):

[in a new window]
  		Figure 3. Case 1. (A) 99Tcm-MDP bone scan (posterior whole body image) shows some distortion of the left iliac crest outline. (B) 111In-pentetreotide whole body scan 24 h post injection shows no abnormality (C,D) 18F-FDG positron emission tomography (coronal sections) show multiple glucose-avid lesions predominantly in the paraaortic region extending above and below the diaphragm. There is minimal involvement of the spine compared with the 123I-MIBG scan (Figure 2DGo).

 


View larger version (80K):

[in a new window]
  		Figure 4. Case 2. (A) 123I-MIBG posterior whole body view 24 h post injection showing abnormal focal but faint uptake in the lung fields, spine and right sacroiliac region. (B) 111In-pentetreotide posterior whole body scan 24 h post injection shows minimal asymmetry in the left sacroiliac joint. (C) 99Tcm-MDP bone scan (posterior whole body view) shows multiple focal areas of increased tracer uptake in the spine, right scapula, some ribs and sacroiliac joints. (D,E) 18F-FDG positron emission tomography (coronal sections) shows multiple glucose-avid lesions predominantly involving lung soft tissues and the spine.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2001 by the British Institute of Radiology.