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Mathematical segmentation of grey matter, white matter and cerebral spinal fluid from MR image pairs

Imaging Science and Biomedical Engineering, University of Manchester, Stopford Medical School, Oxford Road, Manchester M13 9PT, UK

View larger version (88K): [in a new window]   Figure 1. (A) Inversion recovery fast spin echo (IR-FSE) using imaging sequence A (Table 1), providing cancellation of grey and white matter signal (Table 2). (B) IR-FSE using imaging sequence B (Table 1), providing good grey/white matter contrast. (C) IR-FSE using imaging sequence C (Table 1), providing improved grey/white matter contrast. (D) Fluid attenuated inversion recovery fast spin echo using imaging sequence D (Table 1).

View larger version (92K): [in a new window]   Figure 2. (A,B) Tissue density map for grey (A) and white (B) matter using the full linear solutions applied to images A and B. (C,D) Tissue density map for grey (C) and white (D) matter using the full linear solutions applied to images C and D.

View larger version (42K): [in a new window]   Figure 3. (A) Map of measurement error using the original mathematical solution, demonstrating tissue-dependent measurement bias. (B) Histogram of the measurement error showing the bimodal nature and magnitude of the measurement bias.