This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by HILMAN, S Articles by MEIS, J M Search for Related Content PubMed PubMed Citation Articles by HILMAN, S Articles by MEIS, J M

Gastrointestinal stromal tumour with a KIT exon 11 mutation presenting as a paratesticular mass

¹ University Hospital Coventry, Clifford Bridge Road, Coventry CV2 2DX, ² Queen Elizabeth Hospital, Birmingham, Edgbaston, Birmingham B15 2TH, UK, ³ Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Goteberg, Sweden and ⁴ Robert Aitken Institute of Clinical Research, University of Birmingham, Edgbaston, Birmingham, UK

Correspondence: S Hilman, Jackston Barstow Oncology Unit, Weston General Hospital, Grange Road, Uphill, Weston-super-mare, Somerset BS23 4TQ, UK. E-mail: drserena{at}yahoo.co.uk

Gastrointestinal stromal tumours (GISTs) are sarcomas arising in the gastrointestinal tract. They are characterised by a gain in function mutation of the KIT oncogene and the majority express the receptor tyrosine kinase KIT, which can be detected by the immunohistochemical stain CD117. Patients with a GIST present with symptoms such as abdominal pain or gastrointestinal bleeding, or may be asymptomatic. We describe the clinical history and pathological features of a patient with a GIST who presented with a paratesticular mass which, to our knowledge, has never previously been reported. With the development of new drugs to treat GISTs, the knowledge of the type of mutations may in the future prove helpful in determining optimal treatment strategies and prognosis.