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British Journal of Radiology (2009) 82, 123-130
© 2009 British Institute of Radiology
doi: 10.1259/bjr/80083156
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British Journal of Radiology 82 (2009),123-130 ©2009 The British Institute of Radiology

Whole-body adipose tissue analysis: comparison of MRI, CT and dual energy X-ray absorptiometry

J KULLBERG, MS 1 J BRANDBERG, MD 2 J-E ANGELHED, PhD 3 H FRIMMEL, PhD 1 E BERGELIN, RN 3 L STRID, RN 3 H AHLSTRÖM, MD, PhD 1 L JOHANSSON, PhD 1 and L LÖNN, MD, PhD

1 Department of Radiology, Uppsala University Hospital, Uppsala, 2 Department of Radiology, Sahlgrenska University Hospital, Göteborg, 3 Department of Metabolism and Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden and 4 Faculty of Health Sciences, Radiology and Vascular Surgery, Copenhagen University, Denmark

Correspondence: Joel Kullberg, MRT, Entrance 24, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. E-mail: joel.kullberg{at}radiol.uu.se

The aim of this study was to validate a recently proposed MRI-based T1-mapping method for analysis of whole-body adipose tissue (AT) using an established CT protocol as reference and to include results from dual energy X-ray absorptiometry (DEXA). 10 subjects, drawn from the Swedish Obese Subjects Sibling-pairs study, were examined using CT, MRI and DEXA. The CT analysis was based on 28 imaged slices. T1 maps were calculated using contiguous MRI data from two different gradient echo sequences acquired using different flip angles. CT and MRI comparison was performed slice-wise and for the whole-body region. Fat weights were compared between all three modalities. Strong correlations (r≥0.977, p<0.0001) were found between MRI and CT whole-body and AT volumes. MRI visceral AT volume was underestimated by 0.79±0.75 l (p = 0.005), but total AT was not significantly different from that estimated by CT (MRI – CT = –0.61±1.17 l; p = 0.114). DEXA underestimated fat weights by 5.23±1.71 kg (p = 0.005) compared with CT. MRI underestimated whole-body volume by 2.03±1.61 l (p = 0.005) compared with CT. Weights estimated either by CT or by DEXA were not significantly different from weights measured using scales. In conclusion, strong correlations were found between whole-body AT results from CT, MRI-based T1 mapping and DEXA. If the differences between the results from T1-mapping and CT-based analysis are accepted, the T1-mapping method allows fully automated post-processing of whole-body MRI data, allowing longitudinal whole-body studies that are also applicable for children and adolescents.






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