BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (2008) 81, 865-871
© 2008 British Institute of Radiology
doi: 10.1259/bjr/31334499
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ANAND, A K
Right arrow Articles by VAID, A K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ANAND, A K
Right arrow Articles by VAID, A K
British Journal of Radiology 81 (2008),865-871 ©2008 The British Institute of Radiology

Full paper

Favourable impact of intensity-modulated radiation therapy on chronic dysphagia in patients with head and neck cancer

A K ANAND, MD 1 A R CHAUDHOORY, MD 1 A SHUKLA, MD 1 P S NEGI, MSc 2 S N SINHA, MSc 2 A A G BABU, MSc 2 R K MUNJAL, MSc, DipRP 2 A K DEWAN, MCh 3 K KUMAR, MS, FICS 3 D C DOVAL, MAMS 4 and A K VAID, DM 4

Departments of 1 Radiation Oncology, 2 Division of Medical Physics, 3 Surgical Oncology and 4 Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

Correspondence: Anil Kumar Anand, Senior Consultant, Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector – 5, Rohini, New Delhi – 110085, India. E-mail: anandak_55{at}rediffmail.com

The aim of this study was to evaluate the impact of intensity-modulated radiation therapy (IMRT) on the incidence and severity of chronic dysphagia in patients with head and neck cancer. 62 evaluable patients with head and neck cancer who were treated with IMRT with or without concurrent chemotherapy were analysed. The majority of the patients (77.4%) had advanced locoregional disease. 45 patients underwent definitive IMRT and 17 received post-operative IMRT. Concurrent chemotherapy was given to 29 of the 45 patients treated with definitive IMRT. The average prescribed dose to clinical target volume (CTV)1 was 66–70 Gy (definitive IMRT) and 56–62 Gy (post-operative IMRT); 60 Gy to CTV2; 54 Gy to CTV3; and 50–52 Gy to the supraclavicular area. At a median follow-up of 19 months, 2-year actuarial locoregional control and survival was 77% and 74%, respectively. At 6 months after IMRT, chronic dysphagia was Grade 0 in 77.1% of patients, Grade 1 in 10.5% and Grade 2 in 12.3%. Acute mucositis showed no correlation with long-term dysphagia. The percutaneous endoscopic gastrostomy or nasogastric tube was removed in all of the patients within 8 weeks of completion of treatment. Xerostomia was Grade 0 in 61.4% of patients, Grade 1 in 31.5% and Grade 2 in 7% of patients. In conclusion, IMRT conferred a major favourable impact on chronic dysphagia in patients with locally advanced head and neck cancers, with satisfactory locoregional control.




This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
BJR review of the year - 2008.
Br. J. Radiol., March 1, 2009; 82(975): 180 - 182.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2008 by the British Institute of Radiology.