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Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma

Departments of ¹ Radiology, ² Pathology and ³ Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands and ⁴ Department of Radiology, University of Nebraska Medical Center, Omaha, NE, USA

Correspondence: Indra C van den Bos, MD, Department of Radiology, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. E-mail: vandenbos.ic{at}gmail.com

We present a case of a large gallbladder tumour in a patient with no known liver disease and elevated -fetoprotein (AFP), in whom a differential diagnosis from hepatocellular carcinoma (HCC) in a non-cirrhotic liver was particularly difficult given the combination of the size of the tumour, solitary nature, elevated AFP and striking resemblance with HCC at histology. In presenting this patient, we would like to emphasise the role of MRI as a problem-solving tool for analysis of rare tumours of non-hepatocellular origin, including hepatoid adenocarcinoma of the gallbladder.