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First published online October 1, 2007
British Journal of Radiology (2007) 80, 934-938
© 2007 British Institute of Radiology
doi: 10.1259/bjr/25046649
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Short communication

Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride

C B Westbury, MRCP, FRCR 1,2 A Pearson, BSc 1 A Nerurkar, MD 3 J S Reis-Filho, MD, PhD, MRCPath 2 D Steele, BSc 2 C Peckitt, BSc, MSc 4 G Sharp, BSc 1 and J R Yarnold, MRCP, FRCR 1

1 Department of Radiotherapy, The Royal Marsden Hospital, Sutton, Surrey, 2 The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, 3 Department of Pathology, The Royal Marsden Hospital, London,, 4 Clinical Trials and Statistics Unit, Section of Clinical Trials, Institute of Cancer Research, Sutton, UK

Correspondence: Professor John R Yarnold, The Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK. E-mail: john.yarnold{at}icr.ac.uk

Chronic tissue hypoxia may play a role in the pathogenesis of late radiation fibrosis. In order to investigate this hypothesis, the immunohistochemical distribution of pimonidazole hydrochloride (n = 14 patients) and carbonic anhydrase IX (CAIX) (n = 38 patients) was studied in samples of previously irradiated normal human tissue. One sample of irradiated breast tissue, which also showed marked histological features of radiation injury, stained positive for pimonidazole hydrochloride. No CAIX staining was seen in irradiated tissue other than some evidence of physiological hypoxia in the epidermis of two samples of irradiated skin; both were positive for pimonidazole and one was focally positive for CAIX. Pimonidazole hydrochloride staining of tissue with morphological changes of radiation injury could support a role for hypoxia in the pathogenesis of late normal tissue fibrosis in humans.




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