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Radiation-induced skull base leiomyosarcoma presenting with intracerebral haemorrhage

Departments of ¹ Medical Imaging and Intervention and ² Pathology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu Hsing Street, Kwei Shan Hsiang, Tao-Yuan 333, Taiwan

Correspondence: Dr Alex M Wong, 5 Fu Hsing Street, Kwei Shan Hsiang, Tao-Yuan, 333 Taiwan. E-mail: eldomtoh{at}ms53.hinet.net

Radiation-induced neoplasm including meningioma, glioma and sarcoma, is an uncommon but known consequence after therapeutic irradiation of pituitary tumour. Radiation-induced leiomyosarcoma due to previous sellar irradiation has only been reported once in the literature. We herein present the second case of radiation-induced leiomyosarcoma that happened 17 years after radiation therapy for pituitary adenoma. The case is unique in its initial presentation, i.e. acute intracerebral haemorrhage. To the best of our knowledge, such an acute and severe presentation has never been reported in radiation-induced neoplasm following radiotherapy for pituitary adenoma.