This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Fernandez Cabezudo, M J Articles by Langer, R D Search for Related Content PubMed PubMed Citation Articles by Fernandez Cabezudo, M J Articles by Langer, R D

Iosimenol, a new non-ionic dimeric contrast medium, does not induce immunoreactivity in the popliteal lymph node assay

Departments of ¹ Biochemistry, ² Pharmacology, ³ Medical Microbiology and ⁴ Radiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Tawam Street, Al Ain, Abu Dhabi, UAE

Correspondence: Professor Ruth D Langer, MD, PhD, Professor, Associate Dean for Clinical Affairs; Professor of Radiology, Faculty of Medicine and Health Sciences, UAE University-FMHS, PO Box 17666, Tawam Street, Al Ain, Abu Dhabi, UAE. E-mail: rlanger{at}uaeu.ac.ae

Animal studies in mice were conducted to determine the potential immunoreactivity of the new non-ionic dimeric contrast medium (CM) iosimenol using the PLNA and flow cytometric analyses. Comparative studies were performed with iodixanol. The known immune-reactive substance strepozotocin (STZ) and vehicle injections served as positive and negative controls, respectively. Our experiments did not show any immunological effect of iosimenol, concluding that the new CM iosimenol may be beneficial for use in high-risk patients.