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British Journal of Radiology (2007) 80, e170-e172
© 2007 British Institute of Radiology
doi: 10.1259/bjr/55455027
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Case report

Neoadjuvant chemotherapy enables R0 resection of locally advanced rectal cancer in a patient with a previously irradiated pelvis

P Sanghera, MRCP, FRCR 1 K Ho, MRCP, FRCR 1 T Muscroft, FRCR 2 and A Hartley, MRCP, FRCR 1,2

1 Cancer Centre, Queen Elizabeth Hospital, Birmingham B15 2TH, 2 Manor Hospital, Walsall, UK

Correspondence: Dr Paul Sanghera, Cancer Centre, Queen Elizabeth Hospital, Birmingham B15 2TH, UK. E-mail: psangy{at}hotmail.com

Pre-operative chemoradiation is frequently employed in an attempt to downstage locally advanced rectal cancer which threatens or involves the circumferential resection margin (CRM) on MRI scanning. We present a case where radiotherapy was contraindicated as the patient had previously been irradiated to a radical dose for prostatic adenocarcinoma. Neoadjuvant capecitabine and oxaliplatin were used to downsize the tumour to permit resection with a clear CRM.






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