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First published online March 28, 2007
British Journal of Radiology (2007) 80, 422-429
© 2007 British Institute of Radiology
doi: 10.1259/bjr/81758556
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Full paper

Spectrum of radiological changes in hypertensive children with reversible posterior leucoencephalopathy

N Prasad, MD, DNB, DM, DNB, MNAMS 1 S Gulati, DM 1 R K Gupta, MD 2 K Sharma, MD 3 K Gulati, MD 2 R K Sharma, FASN 1 and A Gupta, DNB 1

Departments of 1 Nephrology, 2 Radiology and 3 Neuro-opthalmology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Correspondence: Dr Sanjeev Gulati, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. E-mail: sgulati{at}sgpgi.ac.in

We prospectively studied 19 children with severe hypertension to evaluate the spectrum of radiological changes, severity and reversibility of this entity. All of them were subjected to clinical and biochemical evaluation, followed by magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). Headache was seen in 17 children, 13 had confusion and drowsiness, 12 had nausea and vomiting, 10 patients had visual disturbances, seizure and dyspnoea. Only two had focal neurological deficit (one with right facial palsy and another with right lateral rectus palsy). Of these 19 children, 15 patients had hypertensive retinopathy and four had normal fundi. The positive MRI findings in 17/19 patients were: bilateral leukoencephalopathic changes in occipitoparietal region (9/17), diffuse white/grey matter lesion (3/17) patients, brain stem hyperintensity (2/17) and haemorrhagic lesions (3/17). On MRA, 12/19 patients had attenuation of cerebral arteries of different degree. On follow up, MRI findings resolved in all except three patients. All patients had normal MRA on follow up, except one with persistent minimal attenuation of middle cerebral artery and another had spasm in anterior, middle and posterior cerebral arteries. The intracranial abnormalities in these patients with severe hypertension were reversible in many of the cases after control of blood pressure was achieved. We therefore conclude that severe hypertension may lead to leuoencephalopathy, which had a wide radiological spectrum. A better understanding of this complex syndrome may obviate unnecessary investigations and allow management of associated problems in prompt and appropriate ways.




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