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First published online September 27, 2006
British Journal of Radiology (2007) 80, 321-330
© 2007 British Institute of Radiology
doi: 10.1259/bjr/54805002
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Full paper

Correlation between enhancement pattern of hepatocellular carcinoma on real-time contrast-enhanced ultrasound and tumour cellular differentiation on histopathology

G-J Liu, MD1, H-X Xu, MD, PhD1, M-D Lu, MD, DMSc2, X-Y Xie, MD, PhD1, Z-F Xu, MD1, Y-L Zheng, MD1 and J-Y Liang, MD1

Departments of 1 Medical Ultrasonics and 2 Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China

Correspondence: Ming-de Lu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, 510080, People's Republic of China. E-mail: lumd{at}21cn.com

The objective of this study was to evaluate the correlation between the enhancement pattern of hepatocellular carcinoma (HCC) on contrast-enhanced ultrasound (CEUS) and tumour cellular differentiation on histopathology. 189 HCC lesions in 189 patients were retrospectively evaluated with CEUS and histopathological examination. CEUS was performed with SonoVue and contrast pulse sequencing. Histopathological diagnoses were made according to the Edmonson grading system. Significant differences were shown between the time that the HCC became hypoenhancing or remained echogenic in late phase and tumour cellular differentiation (p = 0.006; p = 0.036), but not with the time of commencement of hyperenhancing or commencement of isoenhancing in arterial phase and portal phase (p = 0.164, p = 0.113; p = 0.186, p = 0.070). The timing of HCC becoming hypoenhancing on CEUS is correlated with tumour cellular differentiation; well differentiated tumours wash out more slowly than poorly differentiated ones.




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