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Comparison of cerebral blood volume maps generated from T₂* and T₁ weighted MRI data in intra-axial cerebral tumours

¹ Division of Imaging Science and Biomedical Engineering, Faculty of Medical and Human Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK, ² Department of Radiology, School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA

Correspondence: Professor Alan Jackson, Division of Imaging Science and Biomedical Engineering, Faculty of Medical and Human Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E-mail: alan.jackson{at}man.ac.uk

We compared parametric maps, measured values and value distributions of cerebral blood volume (CBV) derived from (1) first pass T₁ weighted dynamic contrast-enhanced (DCE) data (T₁-CBV) using the recently described leakage profile model and (2) conventional T₂* weighted DCE data (T₂*-CBV) using a conventional curve fitting technique, in nine patients with intraaxial tumours. Regions of interest were defined around enhancing tumour tissue on matched slices. Median tumour values and conspicuity indexes of CBV from the two techniques were compared, demonstrating good correlation (r = 0.667,p<0.05) in enhancing tumour and no significant difference in conspicuity. Pixel-by-pixel scattergrams of values in normal brain in a representative matched slice were produced for each case, which showed excellent correlation (r = 0.96,p<0.001). Distortion of blood vessels around susceptibility interfaces was evident on T₂* CBV but not on T₁ CBV maps. Leakage-free T₁ CBV maps do not suffer from the susceptibility artifacts seen in T₂* CBV maps, although they present comparable biological information.

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