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First published online July 19, 2006
British Journal of Radiology (2007) 80, 113-120
© 2007 British Institute of Radiology
doi: 10.1259/bjr/36793733
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Full paper

Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI

M J White, MPhys 1,6 R L O'Gorman, MSc 2,3 E M Charles-Edwards, MSc 1 P A Kane, MBBS, MRCP, FRCR 4 J B Karani, BSc, MBBS, FRCR 4 M O Leach, PhD, CPhys, FMedSci 1 and J J Totman, MSc 5

1 Cancer Research UK Clinical Magnetic Resonance Research Group, Royal Marsden NHS Trust & Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, Departments of 2 Neuroimaging, 3 Medical Engineering and Physics and 4 Radiology, King's College Hospital, London SE5 9RS, 5 Brain & Body Centre, University of Nottingham, Nottingham NG7 2RD, 6 Centre for Medical Image Computing, Department of Medical Physics, UCL, London WC1E 6BT, UK

Correspondence: Mr Mark J White, Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, Malet Place Engineering Building, University College London, London WC1E 6BT, UK. E-mail: mark.white{at}ucl.ac.uk

The purpose of this study was to adapt the hepatic perfusion index (HPI) methodology previously developed for MRI to derive 3D parametric maps of HPI, and to investigate apparent differences in HPI maps between a group of colorectal cancer patients and controls. To achieve this, a new and simpler approach to HPI calculation which does not require measurements from the aorta or portal vein is introduced, and assessed with large liver regions of interest (ROIs) in patients and controls. Several example HPI maps showing localized variation are then presented. The subject group consisted of 12 patients with known colorectal metastases, and 13 control subjects referred for routine contrast-enhanced spine imaging with no history of neoplastic disease. HPI was evaluated from serial T1 volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Regions of abnormal perfusion were visible on the HPI maps derived for the patient group, manifested as areas of locally increased HPI extending around the visible margins of known metastases evident on the conventional contrast-enhanced images. This method for MR voxel-based parametric mapping of HPI has the potential to demonstrate regional variations in perfusion at the segmental and subsegmental level.




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