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Review article |
1 Department of Surgery, Christie Hospital, Manchester, 2 Drug Development Group, Paterson Institute for Cancer Research, Manchester, 3 Academic Department of Radiation Oncology, University of Manchester, Manchester, 4 Department of Clinical Oncology, Christie Hospital, Manchester, 5 Departments of Surgery, Christie Hospital and University Department of ORL-HNS, Manchester Royal Infirmary, Manchester, UK
Correspondence: Mr J J Homer, University Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9DL, UK.
A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies.
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