This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nishida, H Articles by O'Uchi, T Search for Related Content PubMed PubMed Citation Articles by Nishida, H Articles by O'Uchi, T

MR findings of granulocytic sarcoma of the breasts

¹ Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ² Department of Radiology, Kameda Medical Center, Chiba, Japan

Correspondence: Hiroko Nishida, Department of Internal Medicine, Keio University School of Medicine, 35 Shnanomachi Sinjuku-ku, Tokyo, 160–8582, Japan.

We report a case of isolated extramedullary relapse of acute myeloid leukaemia (AML) that presented as granulocytic sarcoma of both breasts, with no other signs of relapse even in the bone marrow. The T₂ weighted coronal images on MR showed both multiple ill-defined heterogeneous hyperintense masses relative to breast parenchyma; these masses were seen also with a visual washout enhancement. Pathohistological study showed infiltration by myeloblasts, which were relatively uniform in appearance, featuring round or oval nuclei and a small cytoplasm. After chemotherapy and radiotherapy, both breast masses disappeared on MR images. Although the MR findings of granulocytic sarcoma were indistinguishable from those of multicentric carcinoma and malignant lymphoma, the MR images were useful for evaluating and monitoring responses to the treatments, as well as for detecting non-palpable relapsed tumours.