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British Journal of Radiology (2006) 79, 578-583
© 2006 British Institute of Radiology
doi: 10.1259/bjr/18842556
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Full paper

Quantitative colorectal cancer perfusion measurement by multidetector-row CT: does greater tumour coverage improve measurement reproducibility?

V Goh, MA, MRCP, FRCR 1,2 S Halligan, MD, FRCP, FRCR 1 L Gartner, MRCP 1 P Bassett, MSc 1 and C I Bartram, FRCP, FRCS, FRCR 1

1 Intestinal Imaging Centre, St Mark's Hospital, Harrow, 2 Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, UK

Correspondence: Professor Steve Halligan, Intestinal Imaging Centre, St Mark's Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK. Current address: Specialist Radiology, Level 2 Podium, University College Hospital, 235 Euston Road, London NW1 2BU, UK.

The purpose of this study was to determine if greater z-axis tumour coverage improves the reproducibility of quantitative colorectal cancer perfusion measurements using CT. A 65 s perfusion study was acquired following intravenous contrast administration in 10 patients with proven colorectal cancer using a four-detector row scanner. This was repeated within 48 h using identical technical parameters to allow reproducibility assessment. Quantitative tumour blood volume, blood flow, mean transit time and permeability measurements were determined using commercially available software (Perfusion 3.0; GE Healthcare, Waukesha, WI) for data obtained from a 5 mm z-axis tumour coverage, and from a 20 mm z-axis tumour coverage. Measurement reproducibility was assessed using Bland-Altman statistics, for a 5 mm z-axis tumour coverage, and 20 mm z-axis tumour coverage, respectively. The mean difference (95% limits of agreement) for blood volume, blood flow, mean transit time and permeability were 0.04 (–2.50 to +2.43) ml/100 g tissue; +8.80 (–50.5 to +68.0) ml/100 g tissue/min; –0.99 (–8.19 to +6.20) seconds; and +1.20 (–5.42 to +7.83) ml/100 g tissue/min, respectively, for a 5 mm coverage, and –0.04 (–2.61 to +2.53) ml/100 g tissue; +7.40 (–50.3 to +65.0) ml/100 g tissue/min; –2.46 (–12.61 to +7.69) seconds; and –0.23 (–8.31 to +7.85) ml/100 g tissue/min, respectively, for a 20 mm coverage, indicating similar levels of agreement. In conclusion, increasing z-axis coverage does not improve reproducibility of quantitative colorectal cancer perfusion measurements.




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