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British Journal of Radiology (2006) 79, 71-75
© 2006 British Institute of Radiology
doi: 10.1259/bjr/50464795
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Short communication

Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams

M Miura, PhD 1 H Blattmann, PhD 2 E Bräuer-Krisch, BEng 3 A Bravin, PhD 3 A L Hanson, PhD 1 M M Nawrocky, BA 1 P L Micca, BS 1 D N Slatkin, MD 1,4 and J A Laissue, MD 4

1 Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, 2 Niederwiesstrasse 13C, Untersiggenthal, Switzerland, 3 European Synchrotron Radiation Facility, 6 Rue Jules Horowitz, BP 220, Grenoble, France and 4 Pathologisches Institut der Universität Bern, Murtenstrasse 31, Bern, Switzerland

Microbeam radiosurgery (MBRS), also referred to as microbeam radiation therapy (MRT), was tested at the European Synchrotron Radiation Facility (ESRF). The left tibiofibular thigh of a mouse bearing a subcutaneously (sc) implanted mouse model (SCCVII) of aggressive human squamous-cell carcinoma was irradiated in two orthogonal exposures with or without a 16 mm aluminium filter through a multislit collimator (MSC) by arrays of nearly parallel microbeams spaced 200 µm on centre (oc). The peak skin-entrance dose from each exposure was 442 Gy, 625 Gy, or 884 Gy from 35 µm wide beams or 442 Gy from 70 µm wide beams. The 442/35, 625/35, 884/35 and 442/70 MBRSs yielded 25 day, 29 day, 37 day and 35 day median survival times (MST) (post-irradiation), respectively, exceeding the 20 day MST from 35 Gy-irradiation of SCCVIIs with a seamless 100 kVp X-ray beam.




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[Abstract] [Full Text] [PDF]


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