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Quantitative analysis of lung and tumour mobility: comparison of two time-resolved MRI sequences

¹ Department of Radiology, German Cancer Research Center, Heidelberg, Germany, ² Department of Diagnostic Radiology, Eberhard Karls University, Tübingen, Germany, ³ Department of Thoracic Surgery, ⁴ Department of Oncology, ⁶ Department of Pneumology, ⁷ Department of Diagnostic Radiology, Clinic for Thoracic Disease, Heidelberg, Germany and ⁵ Department of Radiotherapy, University of Heidelberg, Heidelberg, Germany

Correspondence: Christian Plathow, Department of Radiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

The purpose of this study was to describe the use of parallel imaging technique (PAT) using dynamic MRI in lung and tumour mobility during the breathing cycle. 20 patients with stage I non-small cell lung carcinoma were investigated using two dynamic gradient echo sequences with PAT (TrueFISP (fast imaging with steady precession), and fast low angle shot (FLASH). Craniocaudal distance from the apex to the diaphragm of the thorax and tumour mobility during the breathing cycle were measured. Signal-to-noise ratio (SNR) of the tumour was determined. In spite of the different temporal resolutions both trueFISP and FLASH sequence proved to be adequate to continuously measure lung motion and tumour mobility. SNR of the tumour was significantly higher using the trueFISP sequence than FLASH sequence (20.7±3.6 vs 5.8±2.3, p<0.01). Mobility of the tumour bearing hemithorax was significantly lower compared with the non-tumour bearing hemithorax (p<0.05). Dynamic MRI using PAT allows for continuous quantitative documentation of tumour mobility and lung motion. Because of the higher SNR, trueFISP sequence provides a better delineation of intrapulmonary lesions with a sufficient temporal resolution.