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British Journal of Radiology (2005) 78, 8-10
© 2005 British Institute of Radiology
doi: 10.1259/bjr/51173413

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UKRC 2004 debate

Radiation risk is linear with dose at low doses

K H Chadwick, PhD1 and H P Leenhouts, PhD2

1 Ellerbank, Cowan Head, Kendal, Cumbria LA8 9HX, UK and 2 FredBantinglaan, 6721 BC Bennekom, The Netherlands

Abstract

This paper presents a brief argument, based on a mechanistic approach, to show that radiation risk is linear with radiation dose from zero dose up. Similarities in cellular effects lead to the assumption of a common mechanism and the DNA double strand break is identified as the crucial radiation-induced lesion. A cancer model extends the cellular effects to the main radiation risk providing confirmation of the dose effect for cancer at low doses.




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