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Non-rigid image registration: theory and practice

Division of Imaging Sciences, The Guy's, King's and St. Thomas' School of Medicine, London SE1 9RT, UK

Correspondence: Professor Derek Hill, Division of Imaging Sciences, Thomas Guy House (5th Floor), Guy's Hospital, London SE1 9RT, UK

Image registration is an important enabling technology in medical image analysis. The current emphasis is on development and validation of application-specific non-rigid techniques, but there is already a plethora of techniques and terminology in use. In this paper we discuss the current state of the art of non-rigid registration to put on-going research in context and to highlight current and future clinical applications that might benefit from this technology. The philosophy and motivation underlying non-rigid registration is discussed and a guide to common terminology is presented. The core components of registration systems are described and outstanding issues of validity and validation are confronted.

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