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Spontaneous regression of supratentorial intracerebral Langerhans' cell histiocytosis

¹ Department of Neuroimaging, King's College Hospital, Denmark Hill, London and ² Departments of Neuroradiology and Neurology, Atkinson Morley Hospital, Copse Hill, Wimbledon, London, UK

Langerhans' cell histiocytosis (LCH) describes a group of conditions affecting the reticuloendothelial system. It includes the subtypes of Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma and most often presents in childhood. Intracranial involvement in LCH is usually restricted to the hypothalamic–pituitary axis or involves extra-axial extension from skull vault lesions. Supratentorial intracerebral lesions with mass effect and enhancement have rarely been described and are not included in the magnetic resonance based classification system of neurological LCH. We present the MRI of a patient with multisystem LCH with spontaneous resolution of enhancing temporal lobe lesions.