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The development and application of functional nuclear magnetic resonance to in vivo therapeutic anticancer research

2002 Sir Godfrey Hounsfield lecture delivered at the President's Day, Manchester

The Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and the Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK

Correspondence: Dr A Dzik-Jurasz, GlaxoSmithKline Pharmaceuticals, 891-995 Greenford Road, Bldg 5 Flr 1 Rm 13, London UB6 0HE, UK

A little over 30 years ago, Sir Godfrey Hounsfield and his colleagues revolutionized medical imaging by developing CT scanning. In recent years a combination of improved technology and a deeper understanding of tumour biology have led to the development of imaging based strategies aimed at interrogating tissue structure and function. The prospects of this new technology include the prediction of tumour response and the non-invasive study of conventionally inaccessible yet important pharmacological compartments. This article explores how functional nuclear MRI and spectroscopy have been used in predicting response to anticancer therapy in rectal cancers and to assess the biliary excretion of chemotherapeutics.

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