This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Laking, G R Articles by Price, P M Search for Related Content PubMed PubMed Citation Articles by Laking, G R Articles by Price, P M

Positron emission tomographic imaging of angiogenesis and vascular function

¹ Cancer Research UK PET Oncology Group, Hammersmith Hospital, Du Cane Road, London W12 0NN and ² Academic Department of Radiation Oncology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK

Surrogate markers of clinical outcome are important in anticancer drug research, since clinical criteria of response develop only slowly and may be confounded by other processes than drug effect. The need for surrogate outcome markers is especially great with newer agents that may act by tumour stabilization as opposed to shrinkage. Neoplastic angiogenesis is associated with a number of detectable changes at molecular and microcirculatory levels. Therefore, direct study of angiogenic molecular biology and tumour circulation before during and after treatment may offer useful surrogate markers for vascular-targeted therapies. The main advantage of radiotracer imaging with positron emission tomography (PET) is its functional specificity. This article will review two main areas: (a) the methodology behind PET imaging of tumour blood supply with ¹⁵O-oxygen labelled compounds; and (b) newer tracers in development as markers of angiogenetic biology.

This article has been cited by other articles:

				J. W. Xuan, M. Bygrave, H. Jiang, F. Valiyeva, J. Dunmore-Buyze, D. W. Holdsworth, J. I. Izawa, G. Bauman, M. Moussa, S. F. Winter, et al. Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound Cancer Res., March 15, 2007; 67(6): 2830 - 2839. [Abstract] [Full Text] [PDF]

				J. M. Provenzale Imaging of Angiogenesis: Clinical Techniques and Novel Imaging Methods Am. J. Roentgenol., January 1, 2007; 188(1): 11 - 23. [Abstract] [Full Text] [PDF]