BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

British Journal of Radiology (2003) 76, 153-162
© 2003 British Institute of Radiology
doi: 10.1259/bjr/70653746

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackson, A
Right arrow Articles by Waterton, J C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, A
Right arrow Articles by Waterton, J C

Full Paper

Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma

A Jackson, PhD, FRCR1, G C Jayson, FRCP2, K L Li, PhD2, X P Zhu, MD, PhD2, D R Checkley, MSc3, J J L Tessier, PhD3 and J C Waterton, PhD, MRSC3

1 Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT, 2 Cancer Research Campaign Department Medical Oncology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX and 3 AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

Correspondence: Professor Alan Jackson, Imaging Science and Biomedical Engineering, Stopford Medical School, Oxford Road, Manchester M13 9PT, UK

We have investigated the reproducibility of dynamic contrast enhanced imaging techniques in nine patients with cerebral glioma. Patients were imaged twice with a 2 day interval between scans. Maps were produced of the time taken to achieve 90% enhancement (T90), the maximal intensity change per time interval ratio (MITR), the volume transfer coefficient between plasma and the extravascular extracellular space (Ktrans) and the extravascular extracellular contrast distribution volume, ve. Measurements of Ktrans greater than 1.2 min-1 were used to exclude pixels where first pass perfusion effects dominated the measurement. Measures of the test–retest coefficient of variation (CoV) and intraclass correlation coefficients were used to assess reproducibility for measurements from a volume of interest containing enhancing tissue from the whole tumour. MITR showed poor reproducibility (mean CoV 17.9%, 95% confidence limits for group comparisons 20.2%). T90 showed good reproducibility (mean CoV 7.1%, 95% confidence limits for group comparisons 5.2%). Calculated values of Ktrans and ve also showed good reproducibility (mean CoV 7.7% and 6.2% respectively, 95% confidence limits for group comparisons 6.2% and 4.8%, respectively). We conclude that the measurements of Ktrans and ve derived from pharmacokinetic analysis are sufficiently reproducible to support their use as a biological markers in therapeutic trials.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 2003 by the British Institute of Radiology.