This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Li, K L Articles by Jackson, A Search for Related Content PubMed PubMed Citation Articles by Li, K L Articles by Jackson, A

Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data

¹ Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT and ² AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

Correspondence: Professor A Jackson, Imaging Science and Biomedical Engineering, The Stopford Medical School, University of Manchester, Manchester M13 9PT, UK

We describe a novel method for the calculation of endothelial permeability surface area product from dynamic contrast enhanced MRI. The technique uses iterative estimation to automatically decompose tissue residue function into intravascular and extravascular components, which are subsequently used to generate tumour blood volume, which is equal to relative cerebral blood volume calculated from T₁ weighted images and corrected for contamination by contrast agent leakage (), and endothelial permeability (k_fp) maps. The technique was assessed in patients with cerebral glioma (n=5) by examining the reproducibility of endothelial permeability and between two separate examinations conducted with a 2-day interval. The technique produces maps of endothelial permeability that appear to be free of any contribution from intravascular contrast agent. Maps of show close correlation with maps of blood volume calculated from independently acquired dynamic susceptibility weighted MRI examinations, with no evidence of residual permeability effects. The results were highly reproducible with strong intra-class correlation between the two examinations for mean values and for 97.5 percentiles of endothelial permeability and . The excellent reproducibility of this technique and the ability to calculate endothelial permeability and values from rapidly acquired data sets offer considerable advantages over conventional approaches and support the use of this methodology for therapeutic monitoring or trials of novel therapeutic agents.

This article has been cited by other articles:

				L.S. Hu, L.C. Baxter, K.A. Smith, B.G. Feuerstein, J.P. Karis, J.M. Eschbacher, S.W. Coons, P. Nakaji, R.F. Yeh, J. Debbins, et al. Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 552 - 558. [Abstract] [Full Text] [PDF]

				H.S. Kim and S.Y. Kim A Prospective Study on the Added Value of Pulsed Arterial Spin-Labeling and Apparent Diffusion Coefficients in the Grading of Gliomas AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1693 - 1699. [Abstract] [Full Text] [PDF]

				S. Cha, J.M. Lupo, M.-H. Chen, K.R. Lamborn, M.W. McDermott, M.S. Berger, S.J. Nelson, and W.P. Dillon Differentiation of Glioblastoma Multiforme and Single Brain Metastasis by Peak Height and Percentage of Signal Intensity Recovery Derived from Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1078 - 1084. [Abstract] [Full Text] [PDF]

				M. Law, R. Young, J. Babb, M. Rad, T. Sasaki, D. Zagzag, and G. Johnson Comparing Perfusion Metrics Obtained from a Single Compartment Versus Pharmacokinetic Modeling Methods Using Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1975 - 1982. [Abstract] [Full Text] [PDF]

				J. M. Provenzale, G. York, M. G. Moya, L. Parks, M. Choma, S. Kealey, P. Cole, and H. Serajuddin Correlation of Relative Permeability and Relative Cerebral Blood Volume in High-Grade Cerebral Neoplasms Am. J. Roentgenol., October 1, 2006; 187(4): 1036 - 1042. [Abstract] [Full Text] [PDF]

				J. M. Provenzale, S. Mukundan, and D. P. Barboriak Diffusion-weighted and Perfusion MR Imaging for Brain Tumor Characterization and Assessment of Treatment Response. Radiology, June 1, 2006; 239(3): 632 - 649. [Abstract] [Full Text] [PDF]

				S.J. Mills, T.A. Patankar, H.A. Haroon, D. Baleriaux, R. Swindell, and A. Jackson Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma? AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 853 - 858. [Abstract] [Full Text] [PDF]

				S. Cha, L. Yang, G. Johnson, A. Lai, M.-H. Chen, T. Tihan, M. Wendland, and W.P. Dillon Comparison of Microvascular Permeability Measurements, Ktrans, Determined with Conventional Steady-State T1-Weighted and First-Pass T2*-Weighted MR Imaging Methods in Gliomas and Meningiomas. AJNR Am. J. Neuroradiol., February 1, 2006; 27(2): 409 - 417. [Abstract] [Full Text] [PDF]

				T. F. Patankar, H. A. Haroon, S. J. Mills, D. Baleriaux, D. L. Buckley, G. J.M. Parker, and A. Jackson Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas? AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2455 - 2465. [Abstract] [Full Text] [PDF]

				J. M. Provenzale, S. Mukundan, and M. Dewhirst The Role of Blood-Brain Barrier Permeability in Brain Tumor Imaging and Therapeutics Am. J. Roentgenol., September 1, 2005; 185(3): 763 - 767. [Abstract] [Full Text] [PDF]

				J. M. Lupo, S. Cha, S. M. Chang, and S. J. Nelson Dynamic Susceptibility-Weighted Perfusion Imaging of High-Grade Gliomas: Characterization of Spatial Heterogeneity AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1446 - 1454. [Abstract] [Full Text] [PDF]

				J. C. Miller, H. H. Pien, D. Sahani, A. G. Sorensen, and J. H. Thrall Imaging Angiogenesis: Applications and Potential for Drug Development J Natl Cancer Inst, February 2, 2005; 97(3): 172 - 187. [Abstract] [Full Text] [PDF]

				A Jackson Analysis of dynamic contrast enhanced MRI Br. J. Radiol., December 1, 2004; 77(suppl_2): S154 - S166. [Full Text] [PDF]

				M. Law, K. Kazmi, S. Wetzel, E. Wang, C. Iacob, D. Zagzag, J. G. Golfinos, and G. Johnson Dynamic Susceptibility Contrast-Enhanced Perfusion and Conventional MR Imaging Findings for Adult Patients with Cerebral Primitive Neuroectodermal Tumors AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 997 - 1005. [Abstract] [Full Text] [PDF]

				M. Law, S. Yang, J. S. Babb, E. A. Knopp, J. G. Golfinos, D. Zagzag, and G. Johnson Comparison of Cerebral Blood Volume and Vascular Permeability from Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 746 - 755. [Abstract] [Full Text] [PDF]