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British Journal of Radiology 75 (2002),478-481 © 2002 The British Institute of Radiology

Case report

The comedo skin reaction to radiotherapy

W M C Martin, FRCR, FRCP, PhD 1 and A F Bardsley, MB ChB, FRCS (Plastic Surg) 2

1 Oncology Department, Norfolk and Norwich Hospital, Brunswick Road, Norwich NR1 3SR and 2 Plastic Surgery Department, West Norwich Hospital, Bowthorpe Road, Norwich NR2 3TU, UK

A 50-year-old man had a maxillectomy and post-operative radiotherapy for squamous carcinoma of the maxilla. The acute skin reaction merged at 2 months into a chronic comedo-type acneiform skin reaction in the irradiated area. Previous literature on this reaction to radiation is reviewed. The reaction is rare and occurs mostly in the head and neck area, more commonly in patients who have received acneigenic drugs, and with a latent period of between 2 weeks and 6 months from completion of radiotherapy. The pathogenesis of acne is discussed and a mechanism of post-irradiation acne is suggested.






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