This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, H Articles by Endo, K Search for Related Content PubMed PubMed Citation Articles by Zhang, H Articles by Endo, K

Oncological diagnosis using positron coincidence gamma camera with fluorodeoxyglucose in comparison with dedicated PET

¹ Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Showa-machi 3-39-22, Maebashi, Gunma 371-8511 and ² Department of Medical Imaging, National Institute of Radiological Sciences, 9-1, Anagawa-4, Inage-ku, Chiba 263-8555, Japan

Correspondence: Hong Zhang, DMSc, Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Showa-machi 3-39-22, Maebashi, Gunma 371-8511, Japan.

The purpose of this study was to compare the utility of a dual-head positron coincidence detection gamma camera (PCD) with that of dedicated positron emission tomography (PET) in the imaging of various malignancies using ¹⁸F-fluorodeoxyglucose (FDG). 25 patients with known or suspected malignancies at various sites underwent imaging with both methods, and diagnostic performance on a lesion basis was compared. Tumour lesions were analyzed visually and semi-quantitatively using the ratio of tumour-to-background counts (T/B ratio). FDG PCD and FDG PET visually detected 34 (72.3%) lesions and 37 (78.7%) lesions, respectively. The mean T/B ratio and standard deviation (SD) of FDG PCD was 3.5±3.3, significantly lower than that of FDG PET (8.4±7.1, p<0.001). When tumour lesions were less than 2.0 cm in diameter, the sensitivity of FDG PCD was 37.5%, significantly inferior to that of FDG PET (50.0%, p<0.01). Sensitivity between FDG PCD and FDG PET in lesions of more than 2.0 cm diameter showed no statistically significant difference. This study indicates that FDG imaging with a dual-head coincidence detection gamma camera can provide suitable diagnostic performance for lesions greater than 2.0 cm diameter, but performed significantly worse than dedicated PET for lesions smaller than this.

This article has been cited by other articles:

				T. C. Kwee, R. M. Kwee, and R. A. J. Nievelstein Imaging in staging of malignant lymphoma: a systematic review Blood, January 15, 2008; 111(2): 504 - 516. [Abstract] [Full Text] [PDF]

				E. Even-Sapir, B. Yuzefovich, E. Miller, J.-P. Bouhnik, O. Zak, H. Lerman, G. Lievshitz, and C. Levin Coincidence Imaging Using 2 Dual-Head {gamma}-Camera Systems, With and Without Attenuation Correction J. Nucl. Med. Technol., December 1, 2004; 32(4): 190 - 197. [Abstract] [Full Text] [PDF]

				P. S. Oturai, J. Mortensen, H. Enevoldsen, A. Eigtved, V. Backer, K. P. Olesen, H. W. Nielsen, H. Hansen, P. Stentoft, and L. Friberg {gamma}-Camera 18F-FDG PET in Diagnosis and Staging of Patients Presenting with Suspected Lung Cancer and Comparison with Dedicated PET J. Nucl. Med., August 1, 2004; 45(8): 1351 - 1357. [Abstract] [Full Text] [PDF]

				M. K. Kalra, M. M. Maher, G. W. Boland, S. Saini, and A. J. Fischman Correlation of Positron Emission Tomography and CT in Evaluating Pancreatic Tumors: Technical and Clinical Implications Am. J. Roentgenol., August 1, 2003; 181(2): 387 - 393. [Full Text] [PDF]