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British Journal of Radiology 74 (2001),1048-1051 © 2001 The British Institute of Radiology

Short communication

A mammographic dilemma: calcification or haemosiderin as a cause of opacities? Validation of a new digital diagnostic tool

M Yam, DPhil1, J Tchou, MD, PhD2, R English, MBChB, MRCP, FRCR3, R Highnam, DPhil4, R Highnam, DPhil4, D Roskell, MA, BMBCh, MRCPath5, M Greenall, MBChB, ChM, FRCR6 and M Brady, FRS, FEng1

1Medical Vision Laboratory, Robotics Research, Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK, 2Department of General Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Departments of 3Radiology, 5Histopathology and 6Surgery, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Headington, Oxford OX3 9DU, UK and 4Mirada Solutions Ltd., Oxford Centre for Innovation, Mill Street, Oxford OX2 0JX, UK

Core biopsies of an area of microcalcification demonstrated large collections of macrophages containing haemosiderin, with evidence of minimal microcalcification on H&E staining. Algorithms were developed that were capable of differentiating with high accuracy those signs due to calcification, using quantitative measurements such as the apparent volume composition of calcium. Using the linear attenuation coefficients of calcification and assuming an ellipsoid model for the 3-dimensional shape of calcification, we computed the relative calcification volume for each region of interest. The difference in the linear attenuation coefficients of iron and calcification allowed the two to be differentiated on a mammogram based on this measure of relative calcification volume.






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