This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aird, E G Articles by Joiner, M C Search for Related Content PubMed PubMed Citation Articles by Aird, E G Articles by Joiner, M C

A purpose-built iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro

¹ Medical Physics Department, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN ² Gray Laboratory Cancer Research Trust, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

The phenomenon of hyper-radiosensitivity (HRS) to very low acute single doses of radiation has been demonstrated in several cell lines in vitro and in vivo, and has been studied in theory and in practice. The theory suggests a similar hypersensitivity when cells are continuously exposed to radiation at very low dose rates. These low dose rates are used when radioactive seed (iodine-125 or palladium-103) implants of the prostate are used as an alternative to surgery or external beam radiotherapy. To investigate the radiobiology of hypersensitivity of this type on various cell lines in vitro, an iodine-125 seed irradiator has been designed and built for safe use in the Gray Laboratory. In practice, the calculated dose rate has been used for consistency. Discrepancies between calculated and measured dose rates are discussed.

This article has been cited by other articles:

				Y. Liu, J.-l. Liu, Z.-z. Cai, Z. Lu, Y.-h. Dong, Z.-s. Li, Y.-f. Gong, and X.-h. Man A Novel Approach for Treatment of Unresectable Pancreatic Cancer: Design of Radioactive Stents and Trial Studies on Normal Pigs Clin. Cancer Res., June 1, 2007; 13(11): 3326 - 3332. [Abstract] [Full Text] [PDF]