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The British Journal of Radiology, Vol 73, Issue 868 421-424, Copyright © 2000 by British Institute of Radiology

ARTICLES

Magnetic resonance spectroscopy in the evaluation of neurotoxicity following cranial irradiation for childhood cancer

A Davidson, DM Tait, GS Payne, JW Hopewell, MO Leach, M Watson, AD MacVicar, JA Britton and S Ashley
Royal Marsden NHS Trust, Sutton, Surrey, UK.

In order to evaluate the role of proton MR spectroscopy (1H-MRS) in the diagnosis and assessment of long-term radiation-related neurotoxicity, 14 children who had received cranial irradiation for the treatment of childhood leukaemia (n = 6) or brain tumours (n = 8) underwent 1H-MRS, MRI and neuropsychological assessment. Short-term effects at 2 months following treatment were studied in a further three patients. MRI abnormalities were observed in nine patients. No statistically significant differences between patients and controls (n = 17) were seen in any of the calculated 1H-MRS metabolite ratios, in any of the three patient groups. On multivariate logistic regression analysis there was a correlation between the choline/water ratio and a low IQ. It is concluded that any systematic radiation-induced changes in the 1H MRS metabolites must be below the detection threshold of this study.


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