BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (1996) 69, 989-995
© 1996 British Institute of Radiology
doi:
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blomley, M. J.
Right arrow Articles by Dawson, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blomley, M. J.
Right arrow Articles by Dawson, P.

The British Journal of Radiology, Vol 69, Issue 827 989-995, Copyright © 1996 by British Institute of Radiology

ARTICLES

Review article: the quantification of renal function with enhanced computed tomography

MJ Blomley and P Dawson
Department of Diagnostic Radiology, Royal Postgraduate Medical School, London, UK.

The changes with time in renal parenchymal and vascular attenuation following injection of an intravascular contrast medium can be exploited to study renal physiology in several ways. Shortly after injection, both contrast medium clearance and fractional vascular volume per unit volume of kidney can be measured on a regional basis by obtaining sequential CT data from one anatomical level and the application of a graphical analysis to the baseline subtracted CT numbers for tissue and vascular regions of interest: c(t) and b(t), respectively. By plotting the ratio c(t)/b(t) against integral of b(t)dt/b(t), both fractional vascular volume and contrast medium clearance can be estimated graphically. At later time points, a semilogarithmic plot against time of the declining attenuation of vascular or parenchymal regions of interest gives information about overall, as opposed to regional, renal function: the gradient estimates the glomerular filtration rate per unit volume of extracellular fluid. Absolute glomerular filtration rates can also be calculated with blood sampling. Although further experimental evaluation is needed, these techniques have a strong theoretical basis, and experimental work performed so far is encouraging. Possible applications of these techniques are discussed.


This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
N. Hackstein, J. Bauer, E. W. Hauck, M. Ludwig, H.-J. Kramer, and W. S. Rau
Measuring Single-Kidney Glomerular Filtration Rate on Single-Detector Helical CT Using a Two-Point Patlak Plot Technique in Patients with Increased Interstitial Space
Am. J. Roentgenol., July 1, 2003; 181(1): 147 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
K A Miles and M R Griffiths
Perfusion CT: a worthwhile enhancement?
Br. J. Radiol., April 1, 2003; 76(904): 220 - 231.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
N. Hackstein, H. Cengiz, and W. S. Rau
Contrast Media Clearance in a Single Kidney Measured on Multiphasic Helical CT: Results in 50 Patients Without Acute Renal Disorder
Am. J. Roentgenol., January 1, 2002; 178(1): 111 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. D. Krier, E. L. Ritman, Z. Bajzer, J. C. Romero, A. Lerman, and L. O. Lerman
Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function
Am J Physiol Renal Physiol, October 1, 2001; 281(4): F630 - F638.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 1996 by the British Institute of Radiology.