BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (1996) 69, 920-924
© 1996 British Institute of Radiology
doi:
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miyauchi, T.
Right arrow Articles by Katayama, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyauchi, T.
Right arrow Articles by Katayama, H.

The British Journal of Radiology, Vol 69, Issue 826 920-924, Copyright © 1996 by British Institute of Radiology

ARTICLES

Anaphylactic IgE and IgG1 production for hapten can be enhanced by contrast media

T Miyauchi, T Hirano, C Ushiyama, Z Ovary, K Okumura and H Katayama
Department of Radiology, Juntendo University, School of Medicine, Tokyo, Japan.

Various side effects have been associated with the clinical use of contrast media. Immunological mechanisms have been proposed but there have been very few experimental studies with animal models. We have attempted to develop murine models to determine whether or not anaphylactic antibodies such as IgE and IgG1 against hapten (DNP) were enhanced with contrast medium (iopamidol) as an adjuvant or if the contrast medium itself produced antibodies of the IgE class. The results showed that anti-hapten IgE and IgG1 production was greatly enhanced with immunogen plus contrast medium. Anti-contrast medium antibodies of the IgE class could not be detected by PCA reactions. The enhancement of IgE and IgG1 production for hapten was associated with IL-4 release by the neutralization test used by monoclonal anti-IL-4 antibodies. This is the first observation to show that contrast media may have a strong adjuvant effect for the production of IgE and IgG1. This murine model demonstrates a possible immunological function of contrast media in vivo.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
B. G. Papouchado, S. P. Chapoval, E. V. Marietta, C. R. Weiler, and C. S. David
Cockroach Allergen-Induced Eosinophilic Airway Inflammation in HLA-DQ/Human CD4+ Transgenic Mice
J. Immunol., October 15, 2001; 167(8): 4627 - 4634.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 1996 by the British Institute of Radiology.