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Contrast media, endothelin, angioplasty and restenosis

Department of Diagnostic Imaging Northern General Hospital Sheffield S5 7AU

This excerpt was created in the absence of an abstract.

A causal relationship between contrast media (CM), endothelin (ET) and restenosis after angioplasty may exist. In vivo and in vitro studies have shown that CM can stimulate the production of ET, a very potent vasoconstrictor peptide sythesized by the vascular endothelium [1]. In addition to its vasoactive properties ET has mitogenic effects on mesangial and smooth muscle cells [2]. ET can also stimulate the production of growth factors such as the platelet's derived growth factor (PDGF) which is a potent mitogen of smooth muscle and connective tissue cells [3]. A role for PDGF has been proposed in the pathogenesis of restenosis following angioplasty and perhaps in atherogenesis as well [4].

Received for publication January 11, 1995. Accepted for publication January 19, 1995.