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Cellular sensitivity and low dose-rate recovery in Fanconi anaemia fibroblasts

Radiotherapy Research Unit, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey SM2 7NG, UK

Correspondence: ^* Address correspondence to Dr N G Burnet, Meyerstein Institute of Clinical Oncology, Middlesex Hospital, Mortimer Street, London WIN 8AA, UK.

Fanconi anaemia (FA) is a rare inherited condition characterized by developmental abnormalities and progressive bone marrow failure, which requires bone marrow transplantation for successful treatment. This involves the use of alkylating agents and total body or thoraco-abdominal irradiation. Both chemical clastogens and irradiation cause increased chromosome damage in FA cells compared with controls. In some studies FA fibroblasts have been found to be more radiosensitive than normal. From these data it has been inferred that patients with FA might be more sensitive than normal to radiotherapy. However, increased radiosensitivity of FA fibroblasts has not been a uniform finding. The radiosensitivity of fibroblasts from two FA patients was studied at high and low dose-rate (LDR), and their sensitivity compared with normal strains. Both FA strains fell at the sensitive end of the range, but both demonstrated marked dose-rate sparing, with D_0.0l recovery factors of 1.23 and 1.27, similar to the normal strains. These recovery factors are inconsistent with the suggestion that FA patients are recovery deficient. The data indicate that at least some FA strains are capable of LDR recovery, and imply that these patients would probably have a clinical benefit from fractionated or low dose-rate total body irradiation.

Received for publication September 14, 1993. Revision received November 26, 1993. Accepted for publication December 23, 1993.

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