This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rao, V. S. N. Articles by Kavarana, N. M. Search for Related Content PubMed PubMed Citation Articles by Rao, V. S. N. Articles by Kavarana, N. M.

Second malignant neoplasm following treatment of Hodgkin's disease: a case report

V. S. N. Rao, DMRT K. A. Dinshaw, DMRT (Lond), FRCR (Lond) S. K. Shrivastava, MD, DNBR M. A. Muckaden, MD S. Susnerwala, DMRT, MD, DNBR S. H. Advani, MD ^* J. J. Vyas, MS, FACS and N. M. Kavarana, MS

Department of Radiation Oncology, Tata Memorial Hospital, Bombay, India ^* Department of Medical Oncology, Tata Memorial Hospital, Bombay, India Department of Surgical Oncology, Tata Memorial Hospital, Bombay, India Department of Plastic Surgery, Tata Memorial Hospital, Bombay, India

This excerpt was created in the absence of an abstract.

Improvement in the treatment of Hodgkin's Disease (HD) over the past decade has led to increased survival rates, particularly in the early stages. Recognition of long-term complications of the treatment have also increased. Prolonged survival following aggressive treatment of HD is accompanied by an increased risk of the oncogenic effects of radiotherapy and chemotherapy (Halperin etal, 1984). Second malignant neoplasms (SMN) may also develop after the primary has been successfully treated and cured (Kim et al, 1978; Valagussa et al, 1986; Boivin & O'Brien, 1988). We report a case of HD, successfully treated by combined modality treatment developing a chondrosarcoma arising in the chest wall 9 years later.

A 5-year-old female child presented to the Tata Memorial Hospital, in February 1980 with bilateral cervical and left axillary lymphadenopathy of 15 months duration. There was no history suggestive of "B" symptoms. The liver and spleen were not palpable. The chest radiography, bone marrow aspiration and biopsy and lymphogram were all normal. A biopsy of a cervical lymphnode revealed Hodgkin's disease of lymphocyte-predominance type. Thus she was staged clinically as Hodgkin's disease IIA as per the Ann-Arbor classification (Carbone, 1971). The child was treated by radical irradiation with ⁶⁰Co gamma rays to a total dose of 4000 cGy in 20 fractions over 36 days to the mantle field with a further boost of 1000 cGy in 1 week to the left supraclavicular fossa between March and April 1980.

Key Words: Hodgkin's disease • Second malignant neoplasms • Second cancers

Received for publication August 28, 1991. Revision received December 13, 1991. Accepted for publication February 11, 1992.