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British Journal of Radiology (1992) 65, 910-917
© 1992 British Institute of Radiology
doi: 10.1259/0007-1285-65-778-910
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Functional changes in the pig kidney following irradiation with fractionated doses of fast neutrons (42 MeVd->Be)

M. E. C. Robbins, PhD D. W. H. Barnes, MD * J. W. Hopewell, PhD J. F. Knowles, PhD * M. Rezvani, PhD and J. M. Sansom *

CRC Normal Tissue Radiobiology Research Group, Research Institute (University of Oxford), Churchill Hospital, Oxford 0X3 7LJ, UK * MRC Radiobiology Unit, Chilton, Didcot, Oxfordshire 0X11 ORD, UK

The right kidney of female Large White pigs, approximately 14 weeks old, was irradiated with fractionated doses of fast neutrons (42MeVd->Be). The total doses used were 6.6–9.2 Gy. Changes in kidney function, assessed as the functional index (FI, where FI = irradiated kidney function/unirradiated kidney function) or as individual kidney glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), were serially determined up to 104 weeks after irradiation using 99Tcm-DTPA and 13lI-hippuran renography. The animals were then euthanized, the kidneys removed and weighed. A dose-dependent reduction in FI was seen within 13 weeks of irradiation. Measuring individual kidney function revealed a hyperaemic response in both irradiated and unirradiated kidneys 4 weeks after irradiation. This was followed by a dose-dependent reduction in irradiated kidney GFR and particularly ERPF. The ED50 value for the impairment in ERPF, assessed as the percentage of irradiated kidneys exhibiting a ≥ 50% reduction in ERPF, was significantly lower than that for GFR, i.e. 7.20 ± 0.10 Gy compared with 8.44 ± 0.07 Gy (p < 0.001). A dose-related reduction in irradiated kidney weight was also observed. These fast neutron-induced changes in renal function and weight are qualitatively similar to those observed following photon irradiation of the pig kidney.

Key Words: Fast neutrons • Pig kidney • Glomerular filtration rate • Effective renal plasma flow • Kidney weight

Received for publication October 17, 1991. Revision received March 27, 1992. Accepted for publication May 8, 1992.






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